The news about Pfizer's adolescent trial is excellent. As some debate whether we have enough data to reliably estimate vaccine efficacy in this subgroup, some important context is that efficacy was not even the primary outcome of the trial. 1/4 https://t.co/9UWTqn5122
Early on in the pandemic, I tweeted about the need to triangulate results across diverse sources. Vaccine efficacy trials were an exception, being high quality and randomized. With vaccine effectiveness studies based on real-world data, we move back into the first category. 1/3
